Excessive sedation appears to be the main effect of an overdose of mirtazapine.1825 However, little is actually known about drug-drug interactions in the clinical setting.25 Because of its sedative effects, alcohol should not be taken with mirtazapine and excessive sedation may result when it is used with other sedating drugs, such as benzodiazepines.3The usual starting dosage is 15 mg, with a usual dosage range of 15 to 30 mg per day.18 Because of its common sedative effect, it is usually recommended that mirtazapine be taken at bedtime. United States Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research. Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers. Mirtazapine is more effective than trazadone: a double-blind controlled study in hospitalized patients with major depression. A double-blind group comparative study using the new antidepressant Org 3770, placebo and diazepam in patients with expected insomnia and anxiety before elective gynaecological surgery. Actions and interactions of psychotropic drugs on human performance and mood: single doses of ORG 3770, amitriptyline, and diazepam.